The future of biotech: A universal expression system to meet all needs
How to express genes in any host at any level without the limitations of native DNA sequences for production of enzymes, proteins or chemicals?
DURATION: 45 min + 15 min Q&A
Does your current production system meet your future needs? New host systems can create sufficient productivity and capacity for industrial demands. However, the current tools for gene expression control are largely limited to host-specific promoters. This inherently restricts performance improvements and makes it very difficult to introduce novel production hosts into biotechnological use.
Our novel universal expression system enables production of purer proteins and chemicals in wide range of organisms. The universal expression system provides on-demand expression levels and, at the high end, surpassing even the strongest native promoters. Furthermore, this system can be used in a broad spectrum of hosts, including those which were never genetically modified in the past. Why settle for less when you could take a giant leap in productivity?
Key features and benefits of the expression system are:
- Designed to work in every eukaryotic host (fungi, plants, mammals, etc.)
- Saves process development and downstream processing time and costs
- Enables production of purer product and use of simpler media
- Enables fine tuning of metabolic pathways for biochemicals
- It is independent of growth phase or intrinsic metabolic regulation
If you want to improve your current expression system or introduce new hosts which so far resisted your efforts for robust genetic engineering – register to the webinar to discover possible solution for you!
Key learning objectives:
- Understanding the universal expression system concept
- Get to know how to produce high levels of pure proteins
- Learn how to introduce novel production hosts
- Learn how the universal expression system can transform the biotech industry
Contact us for further info about the webinar:
Jussi Jäntti, Research team leader
Jussi Jäntti, PhD (Biochemistry) is a research team leader of the Production Host Engineering Team at VTT. He has over 20 years of experience in yeast cell and molecular biology and biotechnology. He has worked on molecular mechanisms of protein secretion and on means to regulate secretion and productivity of proteins and other compounds. He has over 40 publications, and he has 2 patents/patent application families. Prior to VTT he was a post-doctoral fellow in the University of Cambridge, UK and a research group leader at the University of Helsinki, Finland.
Christopher Landowski, Research team leader
Christopher Landowski, PhD (Pharmaceutical Sciences) is the Research Team Leader of the Protein Production Team at VTT. He has over 15 years of experience in recombinant protein production in bacteria, yeast, and filamentous fungi. His research work at VTT focuses on technologies to improve strain construction, boosting productivity, and reducing secreted protease activity. He is currently Principal Investigator on an Academy of Finland funded research project to study sugar sensing and enzyme secretion in filamentous fungi (2016-2020). Dr. Landowski has published 34 articles and is an inventor in 8 patents. Prior to VTT he was a researcher at the University of Michigan (USA) and Harvard Medical School (USA).
Dominik Mojzita, Senior scientist
Dominik Mojzita, PhD (Microbiology) is a senior scientist in the Production Host Engineering Team at VTT. He has a strong background in molecular biology and genetic engineering of yeast and filamentous fungi. He worked on the identification and characterization of novel genes and metabolic pathways, transcriptional and metabolic regulation, genome-wide and gene-specific expression analysis, the production of organic compounds, single-cell analysis, development of synthetic expression tools and the establishment of synthetic control circuits in yeasts and filamentous fungi. Prior to VTT he was a researcher at the Gothenburg University (Sweden).